¹Department of Pharmacology, Faculty of Pharmacy, University of Inonu, TR-44280 Malatya - TURKEY
²Department of Biochemistry, Faculty of Veterinary Medicine, University of Ataturk, TR-25240 Erzurum - TURKEY
³Department of Statistics, Faculty of Science, University of Firat, TR-23200, Elazig - TURKEY
⁴Department of Pathology, Faculty of Veterinary Medicine, University of Firat, TR-23200 Elazig - TURKEY
⁵Department of Biochemistry, Faculty of Veterinary Medicine, University of Firat, TR-23200 Elazig - TURKEY DOI : 10.9775/kvfd.2016.16094 Approximately 90% of mushroom poisoning deaths in the world is caused by types of Amanita phalloides. Alpha-amanitine has a bicyclic octapeptide structure, which is the main structure responsible for these poisoning cases. In the present study, it was aimed to investigate effects of leaf extracts with artichoke extract on this toxicity. In the study, 28 male rats of Sprague-Dawley species were randomized to 4 groups. The groups were designed as control; receiving serum physiological solution of 0.1 mL intraperitoneally (ip), alpha-amanitine; receiving 3 mg/kg single dose ip, artichoke leaf extract; receiving 1.5 g/kg orally for 14 d, and treatment group¸ receiving alpha-amanitine 3 mg/kg single dose ip+artichoke leaf extract 1.5 g/kg orally for 14 d. It was determined that alpha-amanitine increased hepatic malondialdehyde (MDA) levels, and decrease superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities with decreasing glutathione (GSH) levels. The supplementation with extract with artichoke, decreased MDA levels, it improved antioxidant parameters, and histopathological findings, so it was decided that extract with artichoke juice might be beneficial in alpha-amanitine related hepatic damage. Keywords : Artichoke, Alpha-Amanitine, Amanita phalloides, Antioxidant, Hepatotoxicity