¹Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Qassim University, 51452 Buraidah, SAUDI ARABIA DOI : 10.9775/kvfd.2026.36593 Avian coccidiosis, caused by protozoan parasites of the genus Eimeria remains one of the most economically devastating diseases in poultry production worldwide. Traditional methods of control are mostly based on the use of anticoccidial medication and vaccines; nevertheless, the growing development of drug-resistant strains of the parasites and governmental limitations on the usage of chemotherapeutics have initiated the development of alternative methods of control. Because of the rising concern of antimicrobial resistance, there is a need to develop alternative control strategies. There is an emergence of targeted prebiotics as promising functional feed additives that can be used to regulate the microbiota in the intestine, improve the strength of the mucosal immune system, and improve the integrity of the gut barrier. Prebiotics help to increase intestinal homeostasis and coccidial protection through selective stimulation of positive microbial populations. Moreover, because of better gut health, there could be reduced vulnerability to concomitant parasitic zoonotic pathogens, including Toxoplasma gondii, Cryptosporidium parvum, and Giardia duodenalis. This review investigates the application of targeted prebiotics such as fructo-oligosaccharides, mannan-oligosaccharides, inulin and β-glucans in the reduction of Eimeria infections, poultry performance, and in sustainable poultry production and poultry food safety. Keywords : Eimeria, prebiotics, poultry nutrition, coccidiosis, control, gut microbiota, zoonotic parasites