Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2021 , Vol 27 , Issue 4
The Effects of Diff erent Mydriatics on Intraocular Pressure and Central Corneal Thickness in New Zealand White Rabbits
Latif Emrah YANMAZ1, Sıtkıcan OKUR1, Uğur ERSÖZ1, Mümin Gökhan ŞENOCAK1, Elif DOĞAN2, Zafer OKUMUŞ
1Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, TR-25240 Erzurum - TURKEY
2Department of Surgery, Faculty of Veterinary Medicine, Kastamonu University, TR-37150 Kastamonu - TURKEY
DOI : 10.9775/kvfd.2021.25402 This study was aimed to compare the eff ect of 1% atropine, 1% cyclopentolate, 0.5% tropicamide, and 10% phenylephrine eye drops on intraocular pressure (IOP) and central corneal thickness (CCT) in New Zealand White rabbits. Adult male, eight, New Zealand White rabbits were randomly received each of four mydriatic eye drops separately on left eye at a one-week washout period. Each rabbit received all of five diff erent treatments (sterile saline solution, four mydriatic drugs) on the left eye, whereas no measurements were performed on the right eyes during the experiment. The IOP and CCT recordings of rabbits were performed until the pupil returned to normal diameter. The mean CCT values of sterile saline, 1% atropine, 0.5% tropicamide, 1% cyclopentolate, and 10% phenylephrine were 370±15, 368±17, 372±15, 364±18, and 360±17 μm, respectively, and no statistically significant diff erences (P>0.05) were observed among groups. The mean IOP values of control (sterile saline), 1% atropine, 0.5 % tropicamide, 1% cyclopentolate, and 10% phenylephrine as, 9.7±2.1, 10.4±1.8, 10.3±2.1, 11.0±2.1, and 10±1.8 mmHg, respectively, and these were not statistically significant among groups (P>0.05). In conclusion, topical 1% atropine, 0.5% tropicamide 1% cyclopentolate, and 10% phenylephrine do not have significantly eff ect on IOP and CCT in New Zealand white rabbits. Keywords : Central corneal thickness, Intraocular pressure, Mydriatic, New Zealand white rabbit, Tropicamide