Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2021 , Vol 27 , Issue 1
Inhibition of CD46 Receptor by RNAi Enhances Cell Resistance to BVDV Infection
Ruirui HU1, Liang FENG1, Tao GUO1, Rui YAO1, Yaxin LI1, Xiaokui WANG1, Taotao MI1, Shengwei HU1
1College of Life Sciences, Shihezi University, 832003, Shihezi, Xinjiang, CHINA DOI : 10.9775/kvfd.2020.24679 This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production. Here, we have designed four pairs of effective siRNAs, and in vitro experiments showed that some of them can effectively inhibit the expression of BVDV receptor CD46. Further results showed that BVDV replication was efficiently inhibited and the yield decreased accordingly when expression of CD46 was decreased by siRNA. In conclusion, this study provides a new approach to defend against BVDV infection. Keywords : BVDV, CD46, Replication, RNAi