¹Department of Surgery, Faculty of Veterinary Medicine, Adnan Menderes University, TR-09016 Aydin - TURKEY
²Department of Pathology, Faculty of Veterinary Medicine, Adnan Menderes University, TR-09016 Aydin - TURKEY DOI : 10.9775/kvfd.2019.21976 Investigation of the superiority of the usage of propolis extract, amniotic membrane transplantation, corticosteroid and antibiotic both separately and in different combinations was aimed. A total of 40 (20 male, 20 female) New Zealand breed rabbits weighing 2.5-3.0 kg were used in the study. The rabbits were divided into 5 groups on day 7 of alkali burn injury. Amniotic membrane transplantation was applied to 3 groups and each one of these 3 groups had different local medications as 1% water-based propolis extract (AMN+PRP), dexamethasone and tobramycin (AMN+AC) and only tobramycin (AMN+A). The other two groups, which were not performed amniotic membran transplantation, were either treated with propolis (PRP) or left as a control. The defect area results obtained from AMN+PRP group were lower than AMN+A group, and both AMN+PRP and control group at the day 9 and day 14, respectively (P≤0.05). In the measurements made after the second week, AMN+PRP group showed significantly better results in all weeks in terms of defect area (P≤0.05). Corneal thickness was found to be lower in all groups treated with amniotic membrane than in the other groups (P<0.05). This study aimed to find treatment effectiveness of combining the amniotic membrane with propolis, especially as an anti-inflammatory agent comparing to corticosteroids, and it was decided the outcomes can be improved on the further studies. Keywords : Rabbit, Cornea, Chemical corneal burn, Amniotic membrane, Propolis