¹State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 81016, Qinghai Province, CHINA
²College of Agriculture and Animal Husbandry, Qinghai University, Xining 81016, Qinghai Province, CHINA
³Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining81016, Qinghai Province, CHINA DOI : 10.9775/kvfd.2018.21545 The aims of this study were to investigate whether the Sirtuin 1 (SIRT1) and Hear fatty acid binding protein (H-FABP) genes could be used as candidate genes in the breeding of yak. In 409 indigenous Chinese yaks, two single nucleotide polymorphisms (SNPs) were identified through DNA sequencing technology, including a SNP within the 5"UTR of SIRT1 (g.1906A>G), and a SNP in the exon 1 of H-FABP (g.6643C>T). The chi-square test suggested that all the variations were in Hardy-Weinberg equilibrium (P>0.05). An association analysis suggested that g.1906A>G of SIRT1 gene and g.6643C>T of H-FABP gene exhibited significant correlation with body weight and body length (P<0.01). These results indicated that these SNPs could be used as meritorious and available genetic markers in yak growth traits breeding. Keywords : SIRT1 gene, H-FABP gene, Growth traits, Yak, Single nucleotide polymorphism