¹Bursa Uludag University, Faculty of Veterinary Medicine, Department of Biometry, TR-16059 Bursa - TÜRKİYE
²Bursa Uludag University, Faculty of Veterinary Medicine, Department of Genetics, TR-16059 Bursa - TÜRKİYE DOI : 10.9775/kvfd.2022.27770 Genes or genetic markers related to meat quality have been studied for many years. Th e CAST gene is one candidate gene aff ecting meat tenderness in cattle. Th is meta-analysis aimed to examine the association of c.2832A>G polymorphism of the CAST gene and meat tenderness in cattle. According to the determined criteria, 17 studies were included in the meta-analysis, and pooled ratios of allele and genotype frequencies were calculated. In addition, the combined Warner-Braztler Shear Force values were calculated for three studies that reported these values according to genotypes for the meat tenderness feature. Heterogeneity between studies and publication bias were also tested. As a result of the meta-analysis, pooled ratios of AA, AG, and GG genotypes are 0.578, 0.342, and 0.080; pooled ratios of A and G alleles are 0.777 and 0.223. Th e highest pooled ratios were obtained for AA genotype and A allele. Th e combined Warner-Braztler shear force values were calculated as 3.707, 3.893, and 5.137 kilogram-force for AA, AG, and GG genotypes. Th e highest mean shear force value was obtained for the GG genotype. In conclusion, the meta-analysis results examined the relationship between c.2832A>G polymorphism of the CAST gene and meat tenderness were closer to the population parameter. Th is study may improve genetic selection and provide new strategies to increase meat quality in cattle. Keywords : CAST gene, Cattle, Meta-analysis, Meat tenderness, Polymorphism