¹College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang453003, Henan, P. R. CHINA
²Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang453003, Henan, P. R. CHINA
³Postdoctoral Research Station, Henan Agriculture University, Zhengzhou450046, Henan, P. R. CHINA DOI : 10.9775/kvfd.2021.26849 Inappropriate application of antimicrobial agents can result in resistance by bacteria to drugs and changes in bacterial ecology. In particular, the emergence of multi-drug resistant bacteria seriously aff ects the antibacterial effi cacy of drugs, which threatens the health and lives of humans and animals. Pharmacokinetic/Pharmacodynamic (PK/PD) models can be used to analyze the relationship between PK and PD data and the antibacterial eff ect. PK/PD models provide valuable guidance for optimization of dosage regimens, development of new drugs, setting of susceptibility breakpoints, and analyses of resistant mutants. Th e main models of PK/PD integration are in vitro PK/PD, ex vivo PK/PD, and in vivo PK/PD. Each of these models has its own advantages and disadvantages. Hence, knowing how to choose the appropriate PK/PD model has a huge infl uence on obtaining accurate PK/PD data. In this review, we describe the commonly used PK/PD methods. In this way, we provide a reference for optimizing drug regimens and preventing and controlling drug-resistant bacterial infections. Keywords : Antibacterial drugs, PK/PD integration model, Multi-drug resistance, Dosage regimen optimization, In vivo PK/PD model