¹Atatürk University, Faculty of Veterinary Medicine, Department of Internal Medicine, TR-25240 Erzurum, Türkiye DOI : 10.9775/kvfd.2024.32369 Cutaneous papillomatosis occurs as benign tumoral skin lesions in cattle. Although this condition is most commonly observed in young animals, it can occur in cattle of any age. Although tumor necrosis factor alpha, high mobility group box-1 protein, myxovirus resistance protein-1 have been investigated in various tumoral conditions in human medicine, the relationship between these markers and other hematological indices have not been investigated in bovine papillomatosis with benign tumoral lesions. The purpose of the study is to determine the levels of these markers and their relationship with each other and with hematological indices. The study comprised two groups: the bovine papillomatosis (BP) group, consisting of animals with papillomatosis, and the control group, consisting of healthy animals. Each group consisted of 10 animals of different breeds and genders with an age of 1-2 years. In the BP group, there were significant differences in total leukocyte count, neutrophil count, monocyte count, and neutrophil-lymphocyte ratio values, which were higher, and lymphocyte-monocyte ratio values, which were lower. The levels of high mobility group box-1 protein, myxovirus resistance protein-1, and tumor necrosis factor alpha were significantly higher in the BP group compared to the control group. In conclusion, this study showed that there were significant differences in hematological, inflammation and tumor markers in cutaneous papillomatosis. Anahtar Kelimeler : Bovine haematological values, Cutaneous papillomatosis, High mobility group box-1, Myxovirus resistance protein-1, Tumor necrosis factor alpha