Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2019 , Vol 25 , Issue 2
The Effect of Rocuronium and Sugammadex on Progesterone Levels in Pregnant Rabbits Under General Anesthesia
Rukiye TÜRK1, Semra KAYA2, İlksen DÖNMEZ3, İsa ÖZAYDIN4, Oğuz MERHAN5, Sadık YAYLA4, Celal Şahin ERMUTLU4, Cihan KAÇAR2, Uğur AYDIN4, Özgür AKSOY4, Ürfettin HÜSEYİNOĞLU3
1Kafkas Unıversity, Faculty of Health Science, Department of Obstetrics and Gynecology Nursing, TR-36100 Kars - TURKEY
2Kafkas University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology, TR-36100 Kars - TURKEY
3Kafkas University, Faculty of Medicine, Department of Anesthesiology and Reanimation, TR-36100 Kars - TURKEY
4Kafkas University, Faculty of Veterinary Medicine, Department of Surgery, TR-36100 Kars - TURKEY
DOI : 10.9775/kvfd.2018.20609 The purpose of this study was to investigate the effect of rocuronium and sugammadex on progesterone (P4) levels in pregnant rabbits under general anesthesia. Twenty-one pregnant New Zealand rabbits were used in the study. After the rabbits were divided into three groups of three (Control, Group I and Group II), each animal was given 0.5 mg/kg midazolam and 6 mg/kg propofol and then put under general anesthesia with sevoflurane on the 21st day of pregnancy. No procedure was performed on the control group apart from anesthesia. Rocuronium was administered to GI at the onset of anesthesia, and in GII, sugammadex was administered 60 min after general anesthesia + rocuronium. All of the rabbits were monitored during the anesthesia procedure. A sample of venous blood was taken and biochemically analyzed to test P4 levels. The administration of rocuronium was determined to have caused an increase in the serum progesterone level in all recorded min. Sugammadex was found to cause a quantitative decrease in the level of progesterone. In conclusion, it was found out that rocuronium and sugammadex administration did not have a negative effect on progesterone levels in pregnant rabbits receiving general anesthesia. Keywords : Pregnant, Progesterone level, Rabbit, Sugammadex, Rocuronium