¹Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Qassim University, Buraidah, SAUDI ARABIA DOI : 10.9775/kvfd.2024.33321 Trichinosis is a highly zoonotic disease caused by Trichinella spiralis in humans. The disease is majorly transmitted through the consumption of raw or undercooked meat. About 10000 people get infected with T. spiralis every year. Signs and symptoms of the disease may vary from mild to severe infection, depending on the worm load. Albendazole and mebendazole are two main anthelmintics that have been in use to treat trichinosis for a long time. Albendazole is a very effective drug in the early stages of the T. spiralis infection, but resistance has been reported multiple times. Drug resistance is the most prevailing issue that needs to be addressed as early as possible. Scientists have focused on the development of novel drugs for the treatment of T. spiralis infection. Botanical compounds have multiple medicinal and therapeutic properties which make them able to treat multiple parasitic diseases. Botanical compounds are considered the best alternatives for the development of new drugs for the treatment and control of trichinosis. This review covers the detailed mechanism of action of multiple botanical compounds for a better understanding of the formulation of new drugs. Saponins, tannins, and phenolic acids have potent anthelminthic activity against trichinosis. Keywords : Botanical compounds, Food borne, Food safety, Meat, Mechanisms, Trichinosis, T. spiralis, Zoonosis