¹Atatürk University, Faculty of Veterinary Medicine, Department of Internal Medicine, TR-25240 Erzurum - TÜRKİYE DOI : 10.9775/kvfd.2022.28624 Cardiac complications associated with respiratory diseases are well-documented in humans, but there are not many studies with cattle. Therefore, this study aimed to investigate cardiac damage in cattle with bovine respiratory disease complex (BRDC) with serum heart-type fatty acid-binding protein (H-FABP), N-terminal pro-peptide natriuretic type B (NT-proBNP) and other known cardiac damage biomarkers [cardiac troponin I (cTnI), creatine kinase-myocardial band (CK-MB), creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)]. The material of this study consisted of 20 cattle, aged 4-6 months with BRDC (infected group) and 10 healthy cattle aged 4-6 months (control group). The study findings revealed that leukocyte parameters and serum H-FABP, NT-proBNP, cTnI, CK-MB, CK, LDH, and AST levels were higher in cattle with BRDC (P=0.000). Heart rate and respiratory rate showed a strong positive correlation with cardiac damage markers. ROC analysis revealed that serum H-FABP levels with a cut-off value of 0.45 ng/ml were more sensitive (100%) and specific (100%) than the rest in determining cardiac damage. It was concluded that cardiac damage occurred in cattle with BRDC, and H-FABP was more sensitive and specific in detecting cardiac damage. It is anticipated that the use of biomarkers to detect cardiac injury in BRDC will be important for determining prognosis and guiding treatment. Keywords : BRDC, Cardiac damage, Cattle, cTnI, H-FABP, NT-proBNP