¹Orthopedics and Traumatology Department, Faculty of Medicine, Kafkas University, TR-36100 Kars - TURKEY
²Orthopedics and Traumatology Clinic, Ministry of Health Yavuz Selim Bone Disease Hospital, TR-61030 Trabzon - TURKEY
³Biochemistry Department, Faculty of Medicine, Kafkas University, TR-36100 Kars - TURKEY
⁴Histology and Embryology Department, Faculty of Medicine, Kafkas University TR-36100 Kars - TURKEY DOI : 10.9775/kvfd.2021.25516 This paper aimed to research the possible eff ects of gossypin in a mechano-bio-regulatory mouse model for bone fracture healing. A total of 28 male Mus musculus BALB/c mice were randomly selected. Four groups were created. Each group consisted of 7 mice. The Control group was called Group 1. Group 2 was a femur fractured group of mice without any medication. Group 3 was the dose group of 5 mg/kg gossypin to mouse with femur fractures. Group 4 was the dose group of 10 mg/kg gossypin to mouse with femur fractures. An open fracture model was created in the right femur of the animals in Groups 2, 3, and 4. The radiological views for all groups were taken on postoperative 1st day, 6th week, and 12th week. All samples were obtained, collected, and prepared for biomechanical features, histopathological examinations, biochemical tests, and PCR tests. In terms of radiological and histological results, gossypin showed a significant diff erence depending on the dose in Group 4 to Group 3. Gossypin had sufficient antioxidant and anti-infl ammatory eff ects in mice with femur fracture in bone healing in Groups 3 and 4. Biomechanical tests showed enough hardness levels and high thresholds in braking forces. Keywords : Femur fracture, Mouse, Gossypin, Antioxidant, Anti-infl ammatory