¹Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Orthopaedics and Traumatology, TR-17100 Canakkale - TURKEY
²Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Anesthesiology And Reanimation, TR-17100 Canakkale - TURKEY
³Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Medical Pathology, TR-17100 Canakkale - TURKEY
⁴Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Physiology, TR-17100 Canakkale - TURKEY
⁵Kafkas University, Faculty of Medicine, Department of Physiology, TR-36100 Kars - TURKEY
⁶Kurtalan State Hospital, Department of Orthopaedics and Traumatology, TR-56500 Siirt -TURKEY DOI : 10.9775/kvfd.2018.20793 The effect of ozone treatment in experimental rat gout arthritis was investigated. Twenty adult albino male rats were divided into 4 groups: Group 1 (Control) was followed without any medication, Group 2 (Gout control) was injected with a single dose of 0.2 mL (10 mg) monosodium urate (MSU) intraarticulary to 1st metatarsophalangeal joint to create experimental Gouty arthritis. Group 3 (Gout + Ozone) was injected intraarticulary to 1st metatarsophalangeal joint with a single dose of 0.2 mL (10 mg) MSU to generate experimental gout, followed by ozone therapy to the rats a single dose of 1 mL (10 μg/mL) intraperitoneally daily for 3 weeks. The Group 4 (Ozone control) ozone therapy was given a single dose of 1 mL (10 μg/ mL) intraperitoneally daily for 3 weeks without gout formation. The results were recorded and compared statistically between the groups. In conclusion, the low level of inflammation in the third group (Gout + Ozone) was considered statistically significant as compared to the second group. With Ozone treatment the gout joint has been shown to have reduced acute inflammation, it has not been affected by the chronic proliferation process. Keywords : Gout, Ozone, Immunomodulators, Anti-inflammatory agents