¹Department of Nutrition and Dietetics, Faculty of Health Sciences, Karamanoglu Mehmetbey University, TR-70100 Karaman - Turkey
²Department of Histology and Embryology, Faculty of Veterinary Medicine, Selcuk University, TR-42075 Konya - TURKEY DOI : 10.9775/kvfd.2018.20431 This study was aimed to provide information about the status of the immune system by revealing changes in peripheral blood leukocyte (PBL) percentages, ANAE- and ACP-ase(+) lymphocyte rates in peripheral blood (PB) and endometrium tissues of experimental hypothyroidisminduced rats. In this study, 15 healthy female Wistar Albino rats were used. Rats were fed through 4 weeks. The Group E (experimental, n=9) is group that were made hypothyroidism by intraperitoneal methimazole enjection for 2 weeks. Rats of the Group C (control, n=6) were untreated. In the 2nd and 4th weeks, ANAE- and ACP-ase(+) lymphocyte rates of the Group E were higher than Group C in PB. Excepting eosinophil and basophil leukocyte rates, there was no statistical difference in the other PBL percentages in the both of weeks. In PB, while lymphocyte rate of the 4th week was no statistically different (P>0.05), it was found lower in Group C. There was no alteration in ANAE- and ACP-ase(+) lymphocyte rates of uterine tissue. As a result, whereas hypothyroidism caused significant alterations in PBL and T lymphocyte rates, the any marked changes was not observed in the uterine tissue. Keywords : ACP-ase, ANAE, Endometrium, Hypothyroidism, Methimazole