Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2019 , Vol 25 , Issue 1
Analysis of Pilus Biogenesis Genes in Bacteria Expressing Type IV Pili
Saeed AHMED1, Ijaz AHMAD2, Shakoor AHMAD2, Zahir SHAH2, Muqadar SHAH2, Farhan Anwar KHAN2, Ijaz AHMAD3
1National Reference Laboratory of Veterinary Drug Residue and MOA Key Laboratory for the Detection of Veterinary Drugs Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei 430070, CHINA
2Department of Animal Health, the University of Agricultural Peshawar, PAKISTAN
3Department of Livestock Management, the University of Agricultural Peshawar, PAKISTAN
DOI : 10.9775/kvfd.2018.19910 The structural and sequences similarities of type-IV pili proteins were analysed in Pseudomonas aeruginosa, Vibrio cholerae, Neisseria meningitidis and Neisseria gonorrhoeae. Pathogenic Neisseria species possess pili-genes that code structural and assembly proteins of type-IV pili. A collection of assembly proteins reveal homology amongst P. aeruginosa and Neisseria. While in V. cholerae, these proteins ensure functional counterparts. The pilus retraction and assembly ATPases, PilB/PilF and PilT, PilU are homologous in Neisseria and P. aeruginosa, whereas V. cholerae holds only one ATPase called TcpT. In this work only type-IV pilus machinery of P. aeruginosa shows high likeness with pathogenic Neisseria. Keywords : Type IV pilus genes, Sequence similarity, Pilus machinery, Schematic overview