Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2018 , Vol 24 , Issue 5
Clinical, Bacteriological, and Histopathological Aspects of Endotoxic Pyometra in Bitches
Mürşide Ayşe DEMİREL1, Sevil ATALAY VURAL2, Rıfat VURAL3, Osman KUTSAL2, Ziynet GÜNEN4, Şükrü KÜPLÜLÜ3
1Department of Pharmacology, Faculty of Pharmacy, University of Gazi, TR-06330 Ankara - TURKEY
2Department of Pathology, Faculty of Veterinary Medicine, Ankara University, TR-06110 Ankara - TURKEY
3Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ankara University, TR-06110 Ankara - TURKEY
4Depatment of Pathology, Bornova Veterinary Control Institute, TR-35010 İzmir - TURKEY DOI : 10.9775/kvfd.2018.19675 The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twenty-four bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels were determined. Only alkaline phosphatase levels were significantly different between all groups (P<0.01). Blood endotoxin level was different between the acute and subacute endometritis groups (P<0.01), and subacute endometritis and acute metritis groups (P<0.01). All bitches in the subacute endometritis group recovered. Three bitches in the acute endometritis group, two bitches in the acute metritis group and one bitch in the subacute metritis group died. The blood endotoxin level was determined to be quite high in the dead bitches. There was a difference in the levels of blood urea nitrogen (P<0.05), creatinine (P<0.01), and toxin (P<0.0001) between the dead and surviving bitches. In conclusion, the prognosis of pyometra may be recovered in bitches diagnosed with subacute endometritis associated with low levels of circulating endotoxin. The endotoxemic bitches that have blood endotoxin level above 0.96 EU/mL along with significantly increased alkaline phosphatase, blood urea nitrogen, and creatinine concentration would likely end up with a mortality outcome for acute endometritis, acute metritis, or subacute metritis. These parameters may serve as good prognostic markers in bitches with pyometra. Keywords : Bacteriology, Bitch, Histopathology, Prognosis, Pyometra