¹Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology, TR-31001 Alahan/Antakya, Hatay - TURKEY
²Ankara University, Faculty of Veterinary Medicine, Department of Pathology, TR-06110 Dışkapı, Ankara - TURKEY DOI : 10.9775/kvfd.2016.16417 The aim of this study was to investigate age dependent pathological changes in horse brains. In the study, 10 mature horses aged between 10-16 years, 13 old horses aged between 17-21 years old and 7 young horses between 4-7 years old were examined macroscopically, histopathologically and immunohistohemically. As compared young horse brains; ventricular dilatation, satellitosis, neuronal vacuolization, status spongiosis, ventricular dilatation and ependymal undulation, calcium deposits and axonal swellings were seen in old horse brains. Immunohistochemical staining was obtained with Glial Fibrillary Acidic Protein (GFAP), 2",3"-Cyclic Nucleotide 3"-Phosphodiesterase (CNPase), neuron-specific enolase (NSE), β-amyloid protein (Aβ) antibodies to indicate age related changes in brains. Keywords : Brain, Histopathology, Immunohistochemistry, Old horse