Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2020 , Vol 26 , Issue 1
Polymorphism in GHRH Gene and Its Association with Growth Traits in Tibetan Sheep
Lin-Sheng GUI1, Yang-Yang JIANG3, Gui-Yao LIU2, Jian-Lei JIA3, Ming-De CHU4, Sheng-Zhen HOU1, Zhi-You WANG1
1State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai Province 810016, P. R. CHINA
2Poyang Lake Eco-economy Research Center, Jiujiang University, Jiujiang, Jiangxi Province, 332005, P. R. CHINA
3College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai Province 810016, P. R. CHINA
4Animal Husbandry and Veterinary Station, Menyuan county, Qinghai province, 810016, PEOPLE’S P. R. CHINA
DOI : 10.9775/kvfd.2019.22522 The objectives of this study were to identify single nucleotide polymorphisms (SNPs) in the growth hormone-releasing hormone (GHRH) gene and to evaluate their associations with growth traits in two main Tibetan sheep breeds. Through sequencing technology, four SNPs were identified in the 5"UTR region of GHRH gene. Both g.794A>C and g.1497C>A exhibited significant influence on the growth-related traits in Tibetan sheep (P<0.05 or P<0.01). Hence, the biochemical and physiological functions, together with the results obtained in our investigation, suggest that the GHRH gene could serve as genetic marker for growth in Tibetan sheep breeding. Keywords : Tibetan sheep, Mutation, GHRH gene, Body measurement