Kafkas Üniversitesi Veteriner Fakültesi Dergisi Articles in Press
Comparative Efficacy of Yohimbine and Tolazoline for Antagonism of Ketamine-Xylazine Induced Sedation in Captive Wild Felids
Ameer Hamza RABBANI1, Yasir Razzaq KHAN2, Omer NASEER2, Kashif HUSSEIN2, Ahmad ALI2, Abdul WAHEED3, Muhammad SHAHID1, Hareem AFZAL4
1Department of Surgery, Faculty of Veterinary Sciences, Cholistan University of Veterinary and Animal Sciences, 63100, Bahawalpur, PAKISTAN
2Department of Medicine, Faculty of Veterinary Sciences, Cholistan University of Veterinary and Animal Sciences, 63100, Bahawalpur, PAKISTAN
3Institute of continuing education and extension, Cholistan University of Veterinary and Animal Sciences, 63100, Bahawalpur, PAKISTAN
4Veterinary Officer, Bahria Town, 46220, Rawalpindi, PAKISTAN
DOI : 10.9775/kvfd.2020.25124 This study was conducted to investigate the comparative efficacy of yohimbine and tolazoline for antagonism of ketamine-xylazine induced sedation in captive wild felids in Pakistan. It included 16 tigers (Panthera tigris), 22 lions (Panthera leo) and 16 leopards (Panthera pardus), aged between 2-10 years, weighing approximately 190.6±12.4 kg, 161.6±16.6 kg, and 50.5±6.9 kg respectively. A total of 54 anesthetic inductions were carried out on clinical patients from all species dividing them into two groups KX-T and KX-Y receiving 0.15 mg/kg tolazoline and 0.15 mg/ kg yohimbine as antagonists, respectively. Body temperature, pulse and respiration rate (TPR) were recorded at ten-minute intervals for thirty minutes in either groups. These physiological norms diff ered significantly only in Tigers at 10min and 20min intervals. Furthermore, onset of arousal and recovery time in animals receiving yohimbine was evidently shorter, ranging between 2.8±0.76 to 8.42±0.33 min. ALT, AST, Urea and Creatinine were significantly elevated in groups administered with Tolazoline when compared to Yohimbine as well. Hence, yohimbine at described dosage eff ectively antagonized ketamine and xylazine anesthesia by significant reduction in reversal times for all the species under consideration, bearing nominal deleterious eff ects on physiological, hepatic and renal parameters. So, this study concludes yohimbine to be a superior antagonist for ketamine-xylazine anesthetic reversal than tolazoline. Keywords : Leopard, Lion, Reversal, Tiger, Tolazoline, Yohimbine