Kafkas Üniversitesi Veteriner Fakültesi Dergisi Articles in Press
Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats
Mustafa Can GÜLER1, Ayhan TANYELİ1, Ersen ERASLAN2, Fazile Nur EKİNCİ AKDEMİR3, Tuncer NACAR1, Ömer TOPDAĞI4
1Department of Physiology, Faculty of Medicine, Atatürk University, TR-25240 Erzurum - TURKEY
2Department of Physiology, Faculty of Medicine, Bozok University, TR-66900 Yozgat - TURKEY
3Department of Nutrition and Dietetics, High School of Health, Ağrı İbrahim Çeçen University, TR-04100 Ağrı - TURKEY
4Department of Internal Medicine, Faculty of Medicine, Atatürk University, TR-25240 Erzurum - TURKEY
DOI : 10.9775/kvfd.2019.23250 The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion. Keywords : Ischemia reperfusion, Higenamine, Kidney, Oxidative stress, Inflammation, Rat