This Journal is indexed and abstracted in
Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2019 , Vol 25 , Issue 3
Hawthorn (Crataegus oxyacantha) Flavonoid Extract as an Effective Medicinal Plant Derivative to Prevent Pulmonary Hypertension and Heart Failure in Broiler Chickens
Behnam AHMADIPOUR1, Majid KALANTAR2, Seyed Mahdi HOSSEINI3, Zia ur REHMAN3, Farmanullah FARMANULLAH3, Mohammad Hassan KALANTAR4, LiGuo YANG3
1Department of Animal Science, Shahrekord University, Shahrekord 88186-34141, IRAN
2Animal Science Department, Qom Agricultural and Natural Source Research and Education Center (AREEO) Qom Iran, IRAN
3Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, CHINA
4Student Research Committee, Arak University of Medical Science, Arak, IRAN
5Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture Peshawar, PAKISTAN
DOI : 10.9775/kvfd.2018.20930 The aim of this study was to investigate the effect of crateagus flavonoid extract in preventing pulmonary hypertension syndrome (PHS) in broiler chickens reared at high altitude, encountered ascites was evaluated. A 225 day-old broiler chickens (Ross-308) were randomly assigned to three treatments including different drinking levels of crateagus flavonoid extract (0, 0.1, and 0.2 mL per liter of drinking water) in a 42-day trial. Body weight gain were increased and feed conversion ratio were decreased significantly (P<0.05) when crateagus flavonoid extract was consumed by broiler chickens at levels of 0.1 and 0.2 mL per liter of drinking water in the both starting and growing stages, and throughout the trial. Overexpression of inducible nitric-oxide synthase in the heart was observed in chickens consumed different levels of crateagus flavonoid extract. Birds received crateagus flavonoid extract at levels of 0.1 and 0.2 mL had significantly (P<0.05) higher circulatory concentrations of nitric oxide but significantly (P<0.05) lower serum malondialdehyde concentration, hematocrit and heterophil to lymphocyte ratio compared to control group. Consuming crateagus flavonoid extract at levels of 0.1 and 0.2 mL reduced incidence of right ventricular hypertrophy and led to a significant decline in mortality from PHS. It was concluded that crateagus flavonoid extract is an effective medicinal plant derivative to prevent PHS and ascites in broiler chickens by lowering pulmonary blood pressure and increasing serum antioxidant capacities. Keywords : Chicken, Crateagus flavonoid extract, Cardiac disorder, Gene expression, Ascites