This Journal is indexed and abstracted in
Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2017 , Vol 23 , Issue 3
Evaluation of Paraoxonase Activity, Total Sialic Acid and Oxidative Stress in Sheep with Ecthyma Contagiosa
DEVECİ HA1, KÜKÜRT A2, UZLU E3, SÖZDUTMAZ İ4, MERHAN O2, AKTAŞ S5, ALPAY M6, KAYA İ7, KARAPEHLİVAN M8
1Gaziantep Üniversitesi, Islahiye Meslek Yüksekokulu, TR-27800 Islahiye, Gaziantep - TÜRKİYE
2Kafkas Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, TR-36100 Kars - TÜRKİYE
3Kafkas Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-36100 Kars - TÜRKİYE
4Erciyes Üniversitesi, Veteriner Fakültesi, Viroloji Anabilim Dalı, TR-38000 Kayseri - TÜRKİYE
5Ataturk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-25100 Erzurum - TÜRKİYE
6Düzce Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, TR-81620 Düzce - TÜRKİYE
7Kafkas Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, TR-36100 Kars - TÜRKİYE
8Kafkas Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, TR-36100 Kars - TÜRKİYE
DOI : 10.9775/kvfd.2016.17001 Zoonoses are defined by the world health organization as diseases and infections which are transmitted naturally between vertebrate animals and human. Undestanding the zoonotic risk posed by pox viruses in companion animals is important for both human and animal health. contagious ecthyma is highly contagious, zoonotic, viral skin disease that affects sheep, goats and some other domesticated and wild animals. In this present study was detected and evaluated levels of plasma paraoxonase activity (PON1), high-density lipoprotein (HDL), total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO) and total blood glutathione (GSH) concentrations in healthy sheep and natural infected sheeps with ecthyma. In healthy sheep, laboratory results were determined as PON1 218.54±17.93 U/L, TSA 59.89±5.59 mg/ dL, HDL 48.4±4.88 mg/dL, MDA 8.58±0.80 μmol/L, NO 7.78±1.02 μmol/L and GSH 21.11±3.70 mg/dL. These values were found 174.92±18.68 U/L, 70.1±6.56 mg/dL, 37.9±6.47 mg/dL, 11.26±1.06 µmol/L, 12.44±1.90 µmol/L, 7.79±0.90 mg/dL respectively in sheeps wich are infected by ecthyma. As a result, it was concluded that there is oxidative stress due to imbalance between pro-oxidant and antioxidant molecules in sheep which are infected by ecthyma, and this imbalance is shaped by increasing oxidant levels. Keywords : Ecthyma, Paraoxonase activity, Total sialic acid, Oxidative stress, Sheep