Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2017 , Vol 23 , Issue 2
Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey
BİLGEN N1, ÇINAR KUL B1, ERTUĞRUL O1, ERZURUM F2
1Department of Animal Genetics, Faculty of Veterinary Medicine, University of Ankara, TR-06110 Ankara - TURKEY
2General Directory of Agricultural Farms (TIGEM), TR-06550 Ankara - TURKEY
DOI : 10.9775/kvfd.2016.16213 Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MYO5A) leads frame shift mutation and premature termination of the protein. In the study, a total of 239 blood samples, taken from Anadolu (n=70), Karacabey (n=70) and Sultansuyu (n=99) stud farms were screened. Diseases related mutations were not detected in the sampled Arabian horse population. Keywords : Arabian horses, LFS, PCR-RFLP, PSSM-I