Kafkas Üniversitesi Veteriner Fakültesi Dergisi Articles in Press
Evaluation of Serum Amyloid A and Procalcitonin in Some Inflammatory Diseases of Cattle
Onur BASBUG1, Ibrahim YURDAKUL2, Murat YUKSEL3
1Department of Internal Medicine, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, TR-58140 Sivas - TURKEY
2Department of Surgery, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, TR-58140 Sivas - TURKEY
3Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, TR-58140 Sivas - TURKEY
DOI : 10.9775/kvfd.2019.23412 Recent study in humans and animal has been focused on inflammatory biomarkers that infectious diseases, such as serum amyloid A (SAA), procalcitonin (PCT), that may more accurately and efficiently diagnose inflammation. The aim of this study was to evaluate SAA and PCT levels in the diagnosis of cattle with inflammatory disease. Ten healthy control cattle and 64 patients with systemic inflammatory response syndrome (SIRS) were included in cattle. Inflammatory disease in cattle was diagnosed based on clinical signs and the laboratory examination in clinically suspected cases. SAA and PCT concentrations were measured with a commercial ELISA assay for cattle. SAA and PCT concentrations in cattle with inflammatory disease were significantly higher than in the healthy controls (respectively, P<0.001, P<0.008). Concentrations of SAA and PCT at admission were significantly (r = 0.376, P<0.01) correlated with outcome in cattle with inflammatory conditions. The cut-off value of SAA and PCT for healthy and inflammatory cattle was determined 28.52 μg/mL and 149.55 pg/mL. In conclusion, PCT levels may be used as an alternative to serum SAA measurement as an indicator of acute inflammation in cattle. Serum PCT concentrations were ~9 times higher in the cattle with peritonitis than in the healthy cattle, suggesting that PCT could be a useful marker of peritonitis in cattle. Keywords : Cattle, Marker, Procalcitonin, Serum amyloid A